Flohé, Leopold <br/><br/>
Glutathione 

 -  Taylor & Francis  CRC Press [Imprint]  2018 
 - 1 online resource 
 - Oxidative Stress and Disease .
<br/><br/> Free-to-read 
<br/><br/> This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione--transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets. Key selling features: Summarizing the way glutathione is involved in stress responses Compiling the multiple ways glutathione affects inflammatory responses Disclosing how glutathione dampens programmed cell death such as ferroptosis Exploring the enigma of how enzymes accelerate glutathione-dependent processes Discussing how detoxification and redox regulation is mediated by glutathionylation Reviewing the ways glutaredoxins catalyze protein disulfide reduction Highlighting the medical impact of glutathione-related metabolic pathways Illustrating the role thiol metabolism of pathogens might play in drug discovery 
<br/><br/><br/>Open licence 
<br/><br/><br/>eng 
<br/><br/><label>ISBN: </label>9780367656997 9780815365327 9781351261760 
<br/><br/><label>Standard No.: </label>10.1201/9781351261760  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Glutathione--Congresses.<br/>Glutathione--Metabolism--Congresses.<br/>Oxidative stress.<br/>Glutathion--Congrès.<br/>Glutathion--Métabolisme--Congrès.<br/>Stress oxydatif.<br/>Biology, life sciences<br/>Cellular biology (cytology)<br/>Glutathione<br/>Glutathione--Metabolism<br/>Mathematics and Science<br/>Medicine and Nursing<br/>Molecular biology<br/>Oxidative stress<br/>Pre-clinical medicine: basic sciences<br/>SCIENCE--Life Sciences--Biochemistry.<br/>Glutathione--metabolism<br/>Glutathione--biosynthesis<br/>Glutathione--physiology<br/>Oxidative Stress
<br/><br/><label>Subjects--Index Terms: </label>Active Site Cysteine Adaptive Stress Response Anna Dorothee Engelke Anna P. Kipp Antonella Roveri Bengt Mannervik Biosynthesis Birgitta Sjödin BLM. BrandPedre Carsten Berndt Detoxification Diane E. Handy Drug Discovery Dual Specificity Protein Phosphatase FeS Clusters Free GSH Friedmann Angeli Fulvio Ursini GCL Activity GCLC Expression Giorgio Cozza GPx1 Activity GPx1 KO GPx1 mRNA GPx4 Expression GSH Synthesis GSH Transport Haike Antelmann Henry J. Forman Holger Steinbrenner Hongqiao Zhang Iain L. O. Buxton Iron Dependent Lipid Peroxidation Iron Sulfur Clusters Jesper Z. Haeggström Joris Messens José Pedro Joseph Loscalzo Kenneth D. Tew Klaudia Lepka Labile Iron Pool Lars Bräutigam Lars-Oliver Klotz Laura Orian Lawrence H. Lash Leonardo Astolfi Rosado Leopold Flohé Linda Liedgens LMW Thiol Lucía Piacenza Lutz Schomburg Madia Trujillo Marcel Deponte Marcelo A. Comini Marcus Conrad Martin Hugo Matilde Maiorino Mitochondrial GSH Mixed Disulfide Nico Linzner Per-Johan Jakobsson Protein Tyrosine Phosphata PT