TY  - BOOK
AU  - Flohé,Leopold
AU  - Flohé,Leopold
TI  - Glutathione
T2  - Oxidative Stress and Disease
SN  - 9780367656997
PY  - 2018///
PB  - Taylor & Francis, CRC Press [Imprint]
KW  - Glutathione
KW  - Congresses
KW  - Metabolism
KW  - Oxidative stress
KW  - Glutathion
KW  - Congrès
KW  - Métabolisme
KW  - Stress oxydatif
KW  - Biology, life sciences
KW  - thema
KW  - Cellular biology (cytology)
KW  - fast
KW  - Mathematics and Science
KW  - Medicine and Nursing
KW  - Molecular biology
KW  - Pre-clinical medicine: basic sciences
KW  - SCIENCE
KW  - Life Sciences
KW  - Biochemistry
KW  - bisacsh
KW  - metabolism
KW  - biosynthesis
KW  - physiology
KW  - Oxidative Stress
KW  - Active Site Cysteine
KW  - Adaptive Stress Response
KW  - Anna Dorothee Engelke
KW  - Anna P. Kipp
KW  - Antonella Roveri
KW  - Bengt Mannervik
KW  - Biosynthesis
KW  - Birgitta Sjödin
KW  - BLM
KW  - BrandPedre
KW  - Carsten Berndt
KW  - Detoxification
KW  - Diane E. Handy
KW  - Drug Discovery
KW  - Dual Specificity Protein Phosphatase
KW  - FeS Clusters
KW  - Free GSH
KW  - Friedmann Angeli
KW  - Fulvio Ursini
KW  - GCL Activity
KW  - GCLC Expression
KW  - Giorgio Cozza
KW  - GPx1 Activity
KW  - GPx1 KO
KW  - GPx1 mRNA
KW  - GPx4 Expression
KW  - GSH Synthesis
KW  - GSH Transport
KW  - Haike Antelmann
KW  - Henry J. Forman
KW  - Holger Steinbrenner
KW  - Hongqiao Zhang
KW  - Iain L. O. Buxton
KW  - Iron Dependent Lipid Peroxidation
KW  - Iron Sulfur Clusters
KW  - Jesper Z. Haeggström
KW  - Joris Messens
KW  - José Pedro
KW  - Joseph Loscalzo
KW  - Kenneth D. Tew
KW  - Klaudia Lepka
KW  - Labile Iron Pool
KW  - Lars Bräutigam
KW  - Lars-Oliver Klotz
KW  - Laura Orian
KW  - Lawrence H. Lash
KW  - Leonardo Astolfi Rosado
KW  - Leopold Flohé
KW  - Linda Liedgens
KW  - LMW Thiol
KW  - Lucía Piacenza
KW  - Lutz Schomburg
KW  - Madia Trujillo
KW  - Marcel Deponte
KW  - Marcelo A. Comini
KW  - Marcus Conrad
KW  - Martin Hugo
KW  - Matilde Maiorino
KW  - Mitochondrial GSH
KW  - Mixed Disulfide
KW  - Nico Linzner
KW  - Per-Johan Jakobsson
KW  - Protein Tyrosine Phosphata
KW  - PT
N1  - Free-to-read
N2  - This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione--transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets. Key selling features: Summarizing the way glutathione is involved in stress responses Compiling the multiple ways glutathione affects inflammatory responses Disclosing how glutathione dampens programmed cell death such as ferroptosis Exploring the enigma of how enzymes accelerate glutathione-dependent processes Discussing how detoxification and redox regulation is mediated by glutathionylation Reviewing the ways glutaredoxins catalyze protein disulfide reduction Highlighting the medical impact of glutathione-related metabolic pathways Illustrating the role thiol metabolism of pathogens might play in drug discovery
UR  - https://library.oapen.org/handle/20.500.12657/87680
ER  -