Chondrogianni, Niki <br/><br/>
Proteostasis and Proteolysis 

 -  Taylor & Francis  CRC Press [Imprint]  2022 
 - 1 online resource 
<br/><br/> Free-to-read 
<br/><br/> Proteins are the key decision-making workforce for practically all cellular signals. The precise equilibrium between protein translation, folding, function and timely degradation, also known as "proteostasis", determine cellular health as well as organismal maintenance and survival. Loss of cellular proteostasis is linked with physiological processes of deterioration such as aging, with conditions characterized by supraphysiological oxidative stress as well as with illness, including age-related diseases, neurodegeneration, inflammation, dystrophies and cancer. This book includes 18 chapters logically organized to allow comprehensive understanding of how maintenance of proteostasis protects cellular and organismal health, and how environmental and metabolic pressure can impair proteostasis and lead to disequilibrium and disease. Each chapter contains up-to-date information on its respective topic while some of them review the interplay of certain proteostatic mechanisms, a newly arising topic. Importantly, most chapters include tangible examples of how failure of proteostasis can underlie aging and disease. We hope that the compilation of the above topics will assist both novice and experienced researchers and students to become more familiar with the subject of proteostasis. In the long run, we hope that this book will inspire its readers and eventually promote new ideas and new research studies. 
<br/><br/><br/>Open licence 
<br/><br/><br/>eng 
<br/><br/><label>ISBN: </label>9780367499327 9780367499334 9781003048138 
<br/><br/><label>Standard No.: </label>10.1201/9781003048138  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Biology, life sciences<br/>Chemistry<br/>Mathematics and Science<br/>Medicine and Nursing<br/>Molecular biology<br/>Organic chemistry<br/>Pre-clinical medicine: basic sciences
<br/><br/><label>Subjects--Index Terms: </label>ad age alejandro alihamze anna arantxa aspects assembly Athanasopouloi autophagy between cell central chaerone chapter Chondrogianni complex concluding conculsions contents control crosstalk current deciphering definition degradation Diana diseases during Efstathios Elah elF5A Elisabeth Factors Farras fathinajafabadi Ferrando Ferriz folding functions future gioran gonos heat heidi integrity interplay introsuction irreversible judith kapetanou Kiki kinetic leading localized Marianna Martinez mechanisms MicroRNAs misfolding molecular motifs network Olzscha organellar other oxidative panfilova pathway pauses perspectives pick polu pro process Proteasome protein proteinopathies proteolysis proteome proteostasis proteostatic quality references regulation regulators related remarks rescues response reversible ribosomal riemer rosa RQC shock significance sophia stalling stress system systemic systems table targeting term thermodynamic transcriptional translation translational treatments ubiquitin unfolded