TY  - BOOK
AU  - Chondrogianni,Niki
AU  - Chondrogianni,Niki
AU  - Gioran,Anna
AU  - PICK,ELAH
TI  - Proteostasis and Proteolysis
SN  - 9780367499327
PY  - 2022///
PB  - Taylor & Francis, CRC Press [Imprint]
KW  - Biology, life sciences
KW  - thema
KW  - Chemistry
KW  - Mathematics and Science
KW  - Medicine and Nursing
KW  - Molecular biology
KW  - Organic chemistry
KW  - Pre-clinical medicine: basic sciences
KW  - ad
KW  - age
KW  - alejandro
KW  - alihamze
KW  - anna
KW  - arantxa
KW  - aspects
KW  - assembly
KW  - Athanasopouloi
KW  - autophagy
KW  - between
KW  - cell
KW  - central
KW  - chaerone
KW  - chapter
KW  - Chondrogianni
KW  - complex
KW  - concluding
KW  - conculsions
KW  - contents
KW  - control
KW  - crosstalk
KW  - current
KW  - deciphering
KW  - definition
KW  - degradation
KW  - Diana
KW  - diseases
KW  - during
KW  - Efstathios
KW  - Elah
KW  - elF5A
KW  - Elisabeth
KW  - Factors
KW  - Farras
KW  - fathinajafabadi
KW  - Ferrando
KW  - Ferriz
KW  - folding
KW  - functions
KW  - future
KW  - gioran
KW  - gonos
KW  - heat
KW  - heidi
KW  - integrity
KW  - interplay
KW  - introsuction
KW  - irreversible
KW  - judith
KW  - kapetanou
KW  - Kiki
KW  - kinetic
KW  - leading
KW  - localized
KW  - Marianna
KW  - Martinez
KW  - mechanisms
KW  - MicroRNAs
KW  - misfolding
KW  - molecular
KW  - motifs
KW  - network
KW  - Olzscha
KW  - organellar
KW  - other
KW  - oxidative
KW  - panfilova
KW  - pathway
KW  - pauses
KW  - perspectives
KW  - pick
KW  - polu
KW  - pro
KW  - process
KW  - Proteasome
KW  - protein
KW  - proteinopathies
KW  - proteolysis
KW  - proteome
KW  - proteostasis
KW  - proteostatic
KW  - quality
KW  - references
KW  - regulation
KW  - regulators
KW  - related
KW  - remarks
KW  - rescues
KW  - response
KW  - reversible
KW  - ribosomal
KW  - riemer
KW  - rosa
KW  - RQC
KW  - shock
KW  - significance
KW  - sophia
KW  - stalling
KW  - stress
KW  - system
KW  - systemic
KW  - systems
KW  - table
KW  - targeting
KW  - term
KW  - thermodynamic
KW  - transcriptional
KW  - translation
KW  - translational
KW  - treatments
KW  - ubiquitin
KW  - unfolded
N1  - Free-to-read
N2  - Proteins are the key decision-making workforce for practically all cellular signals. The precise equilibrium between protein translation, folding, function and timely degradation, also known as "proteostasis", determine cellular health as well as organismal maintenance and survival. Loss of cellular proteostasis is linked with physiological processes of deterioration such as aging, with conditions characterized by supraphysiological oxidative stress as well as with illness, including age-related diseases, neurodegeneration, inflammation, dystrophies and cancer. This book includes 18 chapters logically organized to allow comprehensive understanding of how maintenance of proteostasis protects cellular and organismal health, and how environmental and metabolic pressure can impair proteostasis and lead to disequilibrium and disease. Each chapter contains up-to-date information on its respective topic while some of them review the interplay of certain proteostatic mechanisms, a newly arising topic. Importantly, most chapters include tangible examples of how failure of proteostasis can underlie aging and disease. We hope that the compilation of the above topics will assist both novice and experienced researchers and students to become more familiar with the subject of proteostasis. In the long run, we hope that this book will inspire its readers and eventually promote new ideas and new research studies
UR  - https://library.oapen.org/handle/20.500.12657/62946
ER  -